Learning and teaching reform is the core part of basic education reform. In recent years, some schools promoted autonomously learning and teaching reforms which is difficult to carry out deeply and sustainably because of lack of institutional guarantees, professional supports and reform atmosphere from its located region. Promoting learning and teaching reforms by a region as a whole is an effective path. Regional overall reform about learning and teaching is the need of promoting deep and continuous learning and teaching reform of schools and teachers, is the need of promoting the balanced development of education quality among schools in a region, is the need of carrying out the strategy of regional education development. Regional overall reform about learning and teaching must set up three big ideas: firstly, its aim located in all the students'all-round development and individual development, which means that we not only promote students' learning scores and subject knowledge, but also enhance students' comprehensive quality. We not only promote the outstanding students' development, but also improve the students with learning difficulties. Secondly, its subjects include not only schools and teachers, but also education administrators, supporters of the business and the parents which play important roles in learning and teaching reform. It begins from the initial year (such as kindergarten) in order to continuously promote students' development. The strategies of regional overall reform about learning and teaching include: Firstly, re-design regional education management system which include: 1) construct monitoring and evaluation system of students' development in a region; 2) improve incentive system of supporters of the business, schools' administrator and teachers; 3) improve educational management organization structure which clarifies department functions, divides the work reasonably and cooperates closely. Secondly, integrate the reforms of teaching research, scientific research and teacher training in a region which include: 1) break the disciplinary boundaries and do interdisciplinary teaching researches; 2)break the grade boundaries and promote the effective connections between grades; 3) adjust the content of teaching researches and Strengthen the study on student development rules; 4) change the educational research plans in a region, guide teachers to do some little researches about student development and avoid disconnection between teaching researches and teaching practices; 5) reform teacher training in a region and meet the teachers' training demands about learning and teaching reform. At last, improve the family-school collaboration in a region. On the one hand, we need to systematically design and implement parents' training in a region. On the other hand, we need to strengthen the guidance of the contents and styles of family-school communications for schools and teachers in a region.